This study addresses the effect of pre-stressed cables on a pre-stressed mega-braced steel frame through employing static analysis and pushover analysis. The performances of a pre-stressed mega-braced steel frame and a pure steel frame without mega-braces are compared in terms of base shear, ductility, and failure mode. The influence of the cable parameters is also analyzed. Numerical results show that cable braces can effectively improve the lateral stiffness of a pure frame. However, it reduces structural ductility and degenerates structural pre-failure lateral stiffness greatly. Furthermore, it is found that 20% fluctuation in the cable pretension has little effect on structural ultimate bearing capacity and lateral stiffness. As comparison, 20% fluctuation in the cable diameter has much greater impact.