Moisture-associated skin damage from stoma effluent is the most common cause of peristomal skin problems. It is important to identify the causes for any treatment to be effective. A comprehensive assessment should be undertaken using an assessment tool to document the extent of the damage in an accurate and reliable way, and to assist with developing and evaluating a management plan. This article discusses the different types of appliances and accessories that can be used to treat moisture-associated skin damage. As some are costly they should be used wisely. Management of the peristomal skin should be proactive, with the goal being prevention by identifying and managing the causes effectively, thus preventing skin breakdown occurring.