From a psychological viewpoint, coping is a route that develops in milieu of a challenging state or taxing on an individual's present resources. This is a narrative review of the coping concept and why it is an important but misunderstood concept. A comprehensive literature search was carried out in January 2011 using a variety of databases and keywords. The review scrutinised papers to get a definition of coping related to mental health and disease, the nervous, psychology, endocrine and immune systems. This review asserts that coping is the foundation behind wellbeing. More research is required to produce a symbiotic model between psychology and physiology for coping and efforts should collaborate across disciplines—this is achievable. Unequivocally, coping, adaptation and mechanisms are topics to contemplate in future for further understanding.