This paper highlights the role of mathematical programming, particularly linear programming, in training neural networks. A neural network description is given in terms of separating planes in the input space that suggests the use of linear programming for determining these planes. A more standard description in terms of a mean square error in the output space is also given, which leads to the use of unconstrained minimization techniques for training a neural network. The linear programming approach is demonstrated by a brief description of a system for breast cancer diagnosis that has been in use for the last four years at a major medical facility. INFORMS Journal on Computing, ISSN 1091-9856, was published as ORSA Journal on Computing from 1989 to 1995 under ISSN 0899-1499.