Idiopathic membranous nephropathy and anti-phospholipase A2 receptor antibodies.

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2013 English Publisher:Society of Diabetic Nephropathy PreventionJournal:Journal of nephropathology, volume 2 (issn: 2251-8363,

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Authors: Ali Nayer; Arif Asif;

doi: 10.12860/jnp.2013.35

pmid: 24475453

pmc: PMC3891127

Idiopathic membranous nephropathy and anti-phospholipase A2 receptor antibodies.

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Abstract

Implication for health policy/practice/research/medical education: Membranous nephropathy (MN) is a glomerular disease due to subepithelial immune deposits and local complement activation resulting in podocyte injury and proteinuria. Patients with idiopathic (but not secondary) MN had circulating autoantibodies, predominantly of the IgG4 subclass, directed against M-type phospholipase A2 receptor (PLA2R) located on podocytes. It is also possible that the binding of anti-PLA2R antibodies to PLA2R on podocytes could alter receptor function resulting in podocyte dysfunction. Please cite this paper as:Nayer A, Asif A. Idiopathic membranous nephropathy and anti-phospholipase A2 receptor antibodies. J Nephropathology. 2013; 2(4): 214-216, DOI: 10.5812/nephropathol.11627

Related Organizations

Miami University
United States
Albany Medical College
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University System of Ohio
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Albany Medical College
United States

Keywords

Other systems of medicine, end-stage renal disease, nephrotic syndrome, anti-phospholipase a2 receptor antibodies, Pathology, idiopathic membranous nephropathy, RB1-214, Internal medicine, RC31-1245, RZ201-999

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