GNU Radio and OSSIE (Open-Source SCA (Software communication architecture) Implementation-Embedded) are two open source software toolkits for SDR (Software Defined Radio) developments, both of them can be supported by USRP (Universal Software Radio Peripheral). In order to compare the performance of these two toolkits, an FM receiver over GNU Radio and OSSIE are tested in my thesis, test results are showed in Chapter 4 and Chapter 5. Results showed that the FM receiver over GNU Radio has better performance, due to the OSSIE is lack of synchronization between USRP interface and the modulation /demodulation components. Based on this, the SISO (Single Input Single Output) communication system over GNU Radio is designed to transmit and receive sound or image files between two USRP equipped with RFX2400 transceiver at 2.45G frequency. Now, GNU Radio and OSSIE are widely used for academic research, but the future work based on GNU Radio and OSSIE can be designed to support MIMO, sensor network, and real time users etc.