The rapid development of empirical science (physics, biology) and theoretical disciplines (theoretical physics) related to them, results in many theories on the origin, evolution and nature of the world, sometimes interpreted as contradictory to the theological conception. Consequently, under the influence of these achievements, within theology itself a position on the autonomy of both domains and on their complementarity seems to be more and more popular. With regard to this question, it is theology that should present the possibility of an understanding of the revealed truths such that they could coexist with scientific discoveries. Based directly on biblical texts, the sophiological vision of the origin and nature of the world seems to be very interesting among other theological conceptions regarding this question. The present article attempts to confront the presumptions of sophiology regarding the eternal creative Wisdom with the scientific theory of the world’s nature (i.e. its laws), its development (evolution, accidentality of events) and on human existence (e.g. liberty) in order to demonstrate the possibility of the coexistence of these discourses without contradiction.