The purpose of this textbook is to develop the skills of oral speech and reading professionally directed literature in English for students of medical universities, interns, internists, as well as specialists in related fields seeking to deepen their knowledge in the field of clinical medicine in a foreign language. The fundamental principles of therapy (pharmacotherapy, non-medicinal methods, bioethics); clinical aspects (cardiology, pulmonology, gastroenterology, nephrology, hematology, endocrinology); modern approaches (personalized medicine, digital health care, rehabilitation); special sections (gerontology, pediatrics, immunodeficiency, oncology, toxicology) are considered. The publication combines theoretical foundations with practical recommendations, which makes it useful for training and daily clinical work. Meets the requirements of the latest generation of federal state educational standards for higher education. The materials of this textbook are intended both for use in practical classes and for independent work.