Lead Generation of Anti-allergic Agent ; Suplatast Tosilate

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2001 English Publisher:Chem-Bio Informatics SocietyJournal:Chem-Bio Informatics Journal, volume 1, pages 51-59 (issn: 1347-6297, eissn: 1347-0442,

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Authors: Yukio Tada; Ichiro Yamawaki; Shu-ichi Ueda; Hiroshi Matsumoto; Naosuke Matsuura; Mitsugi Yasumoto; Akihide Koda; +1 Authors

doi: 10.1273/cbij.1.51

Lead Generation of Anti-allergic Agent ; Suplatast Tosilate

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Abstract

The reaction of transmethylation plays an important role in the immune system. Some kinds of sulfonium compounds, which have a labile methyl group, are considered to become the supply source for methyl groups in biological systems. We examined the physicochemical properties of sulfonium compounds from the point of structure activity relationships analysis in order to develop an antiallergy drug. We found that several sulfonium compounds have immunological activity, and 2-hydroxyethyldimethylsulfonium p-toluenesulfonate (4) was chosen as the lead compound for further studies.

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Gifu Pharmaceutical University
Japan

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