A Lichen Substance as an Antiproliferative Compound against HL-60 Human Leukemia Cells: 16-O-Acetyl-leucotylic Acid Isolated fromMyelochroa aurulenta
Copyright policy )A Lichen Substance as an Antiproliferative Compound against HL-60 Human Leukemia Cells: 16-O-Acetyl-leucotylic Acid Isolated fromMyelochroa aurulenta
The lichen substance, 16-O-acetyl-leucotylic acid (1), was isolated from an acetone extract of Myelochroa aurulenta and found to exhibit antiproliferative activity against HL-60 human leukemia cells. This is the first report on its anti-leukemia activity (EC(50)=21 microM) which is greater than that of leucotylic acid (2) and the structurally related anti-tumor agent, betulinic acid (4).
- RIKEN Japan
- Akita Prefectural University Japan
Leukemia, Lichens, antiproliferation, Antineoplastic Agents, HL-60 Cells, lichen, Triterpenes, HL-60, 16-<I>O</I>-acetyl-leucotylic acid, Ascomycota, triterpene, Humans, Cell Proliferation
Leukemia, Lichens, antiproliferation, Antineoplastic Agents, HL-60 Cells, lichen, Triterpenes, HL-60, 16-<I>O</I>-acetyl-leucotylic acid, Ascomycota, triterpene, Humans, Cell Proliferation
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).13 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!