Reaction of Retinol with Peroxynitrite
Copyright policy )Reaction of Retinol with Peroxynitrite
The reactivity of retinol with peroxynitrite, which is a strong oxidant and has been reported to induce several biological damages, was investigated. 13-cis-14-nitroretinol (1), 13-trans-14-nitroretinol (2), 13-apo-beta-carotenone (3), retinal (4), 11,14-epoxyretinol (5), and 11,15-epoxyretinol (6) were identified as reaction products of retinol with peroxynitrite. From these results, it was observed that retinol can undergo a nitration reaction with peroxynitrite. Furthermore, the formation mechanisms of 1, 2, and 3 from retinol with peroxynitrite are discussed.
- Shizuoka University Japan
- Meijo University Japan
- Kyoto University Japan
- Gifu University Japan
- Research Institute for Production Development Japan
Nitrates, Molecular Structure, Nitrogen, Stereoisomerism, Vitamin A, Oxidation-Reduction, Chromatography, High Pressure Liquid
Nitrates, Molecular Structure, Nitrogen, Stereoisomerism, Vitamin A, Oxidation-Reduction, Chromatography, High Pressure Liquid
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