Transcriptional Coactivator p300/CBP-Associated Factor and p300/CBP-Associated Factor Type B Are Required for Normal Estrogen Response of the Mouse Uterus
Copyright policy )Transcriptional Coactivator p300/CBP-Associated Factor and p300/CBP-Associated Factor Type B Are Required for Normal Estrogen Response of the Mouse Uterus
Mice with targeted gene disruption of one of the estrogen receptor coactivators, p300/CBP-associated factor (PCAF), and its counterpart, PCAF-B, were used to investigate the possible involvement of PCAF and PCAF-B in estrogen receptor-mediated actions in vivo. Among ovariectomized mice that were treated with estrogen, PCAF and PCAF/PCAF-B knockouts showed abnormal growth of the uterus compared with the wild type. The level of c-fos gene expression in the uterus was not induced by estrogen in the knockouts. These observations suggest that PCAF and PCAF-B are required for estrogen-dependent normal growth of the uterus via estrogen receptor-mediated transcriptional regulations.
- National Institute of Health Pakistan
- Seitoku University Japan
Mice, Knockout, Ovariectomy, Uterus, Genes, fos, Cell Cycle Proteins, Estrogens, p300-CBP-Associated Factor, Mice, Gene Expression Regulation, Receptors, Estrogen, Acetyltransferases, Animals, Female, p300-CBP Transcription Factors, Histone Acetyltransferases, Transcription Factors
Mice, Knockout, Ovariectomy, Uterus, Genes, fos, Cell Cycle Proteins, Estrogens, p300-CBP-Associated Factor, Mice, Gene Expression Regulation, Receptors, Estrogen, Acetyltransferases, Animals, Female, p300-CBP Transcription Factors, Histone Acetyltransferases, Transcription Factors
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