Antigen Feeding Increases Frequency and Antigen-specific Proliferation Ability of Intraepithelial CD4+T Cells in αβ T Cell Receptor Transgenic Mice
Copyright policy )Antigen Feeding Increases Frequency and Antigen-specific Proliferation Ability of Intraepithelial CD4+T Cells in αβ T Cell Receptor Transgenic Mice
To study how intestinal intraepithelial lymphocytes (IEL) are affected by orally ingested antigen, the phenotypes and responses of the IEL in mice expressing a transgenic T cell receptor alphabeta (TCR alphabeta) specific for ovalbumin (OVA) were analyzed after feeding OVA. In the OVA-fed mice, the abundance of alphabeta-IEL as a proportion of the total IEL population increased and the frequency of CD4+ cells increased within the TCR alphabeta+ IEL population. CD4(+) IEL from OVA-fed transgenic mice proliferated in vitro more markedly in response to antigen stimulation than IEL from mice fed the control diet. These results indicate that antigen-specific proliferation of CD4+ IEL was amplified as a result of oral administration of antigen.
- University of Tokyo Japan
- Keio University Japan
- Torrey Pines Institute For Molecular Studies United States
- Tokai University Japan
- Food Research Institute Japan
CD4-Positive T-Lymphocytes, intestinal intraepithelial lymphocytes (IEL), Ovalbumin, Receptors, Antigen, T-Cell, alpha-beta, Administration, Oral, ovalbumin, Mice, Transgenic, transgenic mice, Lymphocyte Activation, Immunophenotyping, Mice, food antigen, Animals, Antigens, Intestinal Mucosa, Cell Division, Cells, Cultured
CD4-Positive T-Lymphocytes, intestinal intraepithelial lymphocytes (IEL), Ovalbumin, Receptors, Antigen, T-Cell, alpha-beta, Administration, Oral, ovalbumin, Mice, Transgenic, transgenic mice, Lymphocyte Activation, Immunophenotyping, Mice, food antigen, Animals, Antigens, Intestinal Mucosa, Cell Division, Cells, Cultured
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).1 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!