Kinetic Resolutions of Indan Derivatives Using Bacteria

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2002 English Publisher:Oxford University Press (OUP)Journal:Bioscience, Biotechnology, and Biochemistry, volume 66, pages 464-466 (issn: 0916-8451, eissn: 1347-6947,

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Authors: Naoki, Tarui; Hayao, Watanabe; Kohji, Fukatsu; Shigenori, Ohkawa; Kazuo, Nakahama;

doi: 10.1271/bbb.66.464

pmid: 11999429

Kinetic Resolutions of Indan Derivatives Using Bacteria

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Abstract

Racemic indan derivatives have been resolved by the hydrolysis of amide bonds using Corynebacterium ammoniagenes IFO12612 to produce (S)-amine and (R)-amides. In the kinetic resolution of 1 (N-12-(6-methoxy-indan-1-yl)ethyl]acetamide), it was possible to run the reaction to 44% conversion on a 10-g scale, obtaining (S)-amine 4 ((S)-2-(6-methoxy-indan-1-yl)ethylamine) at >99% enantiomeric excess (ee) and (R)-1 at 98% ee.

Related Organizations

Takeda (Japan)
Japan

Keywords

Kinetics, Hydrolysis, Indans, Corynebacterium

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