Inhibition of Alpha-glucosidase and Amylase by Luteolin, a Flavonoid

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2000 English Publisher:Oxford University Press (OUP)Journal:Bioscience, Biotechnology, and Biochemistry, volume 64, pages 2,458-2,461 (issn: 0916-8451, eissn: 1347-6947,

Copyright policy )

Authors: KIM, Jong-Sang; KWON, Chong-Suk; SON, Kun Ho;

doi: 10.1271/bbb.64.2458

pmid: 11193416

Inhibition of Alpha-glucosidase and Amylase by Luteolin, a Flavonoid

- Summary
- Subjects
- Metrics

Abstract

Twenty-one naturally occurring flavonoids were tested for inhibitory activities against alpha-glucosidase (EC 3.2.1.20) and alpha-amylase (EC 3.2.1.1). Luteolin, amentoflavone, luteolin 7-O-glucoside, and daidzein were the strongest inhibitors among the compounds tested. Luteolin inhibited alpha-glucosidase by 36% at the concentration of 0.5 mg/ml and was stronger than acarbose, the most widely prescribed drug, in inhibitory potency, suggesting that it has the possibility to effectively suppress postprandial hyperglycemia in patients with non-insulin dependent diabetes mellitus. Luteolin also inhibited alpha-amylase effectively although it was less potent than acarbose. The clinical value of luteolin needs to be further evaluated.

Related Organizations

Kyungpook National University
Korea (Republic of)
Andong National University
Korea (Republic of)

Keywords

Flavonoids, alpha-glucosidase inhibitor, alpha-amylase, alpha-Glucosidases, Isoflavones, Glucosides, Hyperglycemia, flavonoids, Amylases, Biflavonoids, Humans, Glycoside Hydrolase Inhibitors, luteolin, Enzyme Inhibitors, Luteolin

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	552
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 0.1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%