Insecticidal and Antifungal Activities of Aminorhodanine Derivatives
Copyright policy )Insecticidal and Antifungal Activities of Aminorhodanine Derivatives
Aminorhodanine (1) showed strong insecticidal activity against Culex pipiens pallens and Musca domestica, with respective LD50 values of 0.21 microgram/insect and 0.87 microgram/insect. Compound 1 had antifungal activity against Aspergillus niger ATCC-16404, Trichophyton mentagrophytes IFO-32412, Candida albicans ATCC-10231, Hansenula anomala OPS-308 and Penicillium expansum IFO-8800. In particular, 1 had potent antifungal activity against Aspergillus niger ATCC-16404, its minimal inhibitory concentration (MIC) being 6.25 micrograms/ml. Both activities of 1 were much higher than those of rhodanine (4), suggesting that the introduction of an amino group into N-3 of 4 plays an important role in the biological activity of rhodanine-related compounds. On the other hand, N-acetylaminorhodanine (2) and N-benzoylaminorhodanine (3) did not show either activity, suggesting that the free amino group at N-3 of 1 is closely related to the inhibitory activity of rhodanine derivatives.
pathogenic fungus, Insecticides, Antifungal Agents, Rhodanine, antifungal activity, aminorhodanine, Fungi, Microbial Sensitivity Tests, insecticidal activity, Culex, Houseflies, rhodanine, Animals
pathogenic fungus, Insecticides, Antifungal Agents, Rhodanine, antifungal activity, aminorhodanine, Fungi, Microbial Sensitivity Tests, insecticidal activity, Culex, Houseflies, rhodanine, Animals
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