Biological Activity of Purpurogallin

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1997 English Publisher:Informa UK LimitedJournal:Bioscience, Biotechnology, and Biochemistry, volume 61, pages 890-892 (issn: 0916-8451, eissn: 1347-6947,

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Authors: INAMORI, Yoshihiko; MURO, Chikaaki; SAJIMA, Eiko; KATAGIRI, Motoharu; OKAMOTO, Yukiko; TANAKA, Hajime; SAKAGAMI, Yoshikazu; +1 Authors

doi: 10.1271/bbb.61.890

pmid: 9178568

Biological Activity of Purpurogallin

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Abstract

Purpurogallin showed antibacterial activity toward gram-positive bacteria. Strong activity against methicillin-resistant Staphylococcus aureus [minimal inhibitory concentration (MIC) against methicillin of 1600 micrograms/ml] was found, with MIC of 11.0 micrograms/ml. Purpurogallin inhibited the growth of all tested plants and decreased the chlorophyll content in the cotyledons of Brassica campestris subsp. rapa. It showed potent inhibitory activity against prolyl endopeptidase (the 50% inhibitory concentration was 1.6 x 10(-5) M), unlike its analogues, hinokitiol and tropolone.

Related Organizations

Osaka Prefectural Institute of Public Health
Japan
Osaka Medical College
Japan
Osaka University of Pharmaceutical Sciences
Japan

Keywords

Serine Proteinase Inhibitors, Molecular Structure, Serine Endopeptidases, prolyl endopeptidase, methicillin-resistant Staphylcoccus aureus, Brassica, Microbial Sensitivity Tests, Gram-Positive Bacteria, purpurogallin, Tropolone, Anti-Bacterial Agents, Benzocycloheptenes, antibacterial activity, plant growth-inhibitory activity, Gram-Negative Bacteria, Monoterpenes, Prolyl Oligopeptidases

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