Inhibition of Aldose Reductase and Sorbitol Accumulation by Astilbin and Taxifolin Dihydroflavonols inEngelhardtia chrysolepis

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1997 English Publisher:Informa UK LimitedJournal:Bioscience, Biotechnology, and Biochemistry, volume 61, pages 651-654 (issn: 0916-8451, eissn: 1347-6947,

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Authors: HARAGUCHI, Hiroyuki; OHMI, Isao; FUKUDA, Ayumi; TAMURA, Yukiyoshi; MIZUTANI, Kenji; TANAKA, Osamu; CHOU, Wen-Hua;

doi: 10.1271/bbb.61.651

pmid: 9145524

Inhibition of Aldose Reductase and Sorbitol Accumulation by Astilbin and Taxifolin Dihydroflavonols inEngelhardtia chrysolepis

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Abstract

Dihydroflavonol taxifolin and its glycoside, astilbin, from Engelhardtia chrysolepis inhibited rat lens and recombinant human aldose reductase. Taxifolin also inhibited sorbitol accumulation in human red blood cells. Furthermore, this dihydroflavonol aglycone maintained the clarity of rat lens incubated with a high concentration of glucose. These dihydroflavonols may be effective for preventing osmotic stress in hyperglycemia.

Related Organizations

Fukuyama University
Japan
South China Institute of Botany
China (People's Republic of)

Keywords

Flavonoids, Erythrocytes, Flavonols, aldose reductase, Recombinant Proteins, Rats, Trees, taxifolin, sorbitol accumulation, Aldehyde Reductase, Lens, Crystalline, astilbin, Animals, Humans, Sorbitol, Quercetin, Engelharatia chrysolepis

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