Fate of Nicotinamide Differs Due to an Intake of Nicotinamide

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1996 English Publisher:Informa UK LimitedJournal:Bioscience, Biotechnology, and Biochemistry, volume 60, pages 1,204-1,206 (issn: 0916-8451, eissn: 1347-6947,

Copyright policy )

Authors: SHIBATA, Katsumi; SHIMADA, Hisako; TAGUCHI, Hiroshi;

doi: 10.1271/bbb.60.1204

pmid: 8782418

Fate of Nicotinamide Differs Due to an Intake of Nicotinamide

- Summary
- Subjects
- Metrics

Abstract

We found that the catabolism of nicotinamide (Nam) differs due to an intake of Nam itself in rats. When rats were fed with a Nam-free, tryptophan-limiting diet, the major catabolite of niacin was N1-methyl-4-pyridone-3-carboxamide (4-Py). However, its percentage was changed with increasing the intake of Nam. The major metabolite was N1-methylnicotinamide (MNA) in the diet containing 0.006% Nam, or 0.1% Nam. The toxicity of excess Nam was observed when rats were fed with a 0.5% Nam-containing diet. In this diet, the major metabolite was Nam N-oxide and it was noted that the urinary excretion of nicotinic acid and its metabolite nicotinuric acid was observed. Therefore, these acids might be detected only when the toxicity of Nam appears.

Related Organizations

Mie University
Japan
Osaka International University
Japan

Keywords

Male, Niacinamide, N1-methyl-4-pyridone-3-carboxamide, Weight Gain, Diet, Rats, nicotinuric acid, Eating, N1-methylnicotinamide, Liver, Animals, nicotinamide N-oxide, Rats, Wistar, N1-methyl-2-pyridone-5-carboxamide, Biotransformation, Chromatography, High Pressure Liquid

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	16
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average