Boromycin, an Anti-HIV Antibiotic
Copyright policy )Boromycin, an Anti-HIV Antibiotic
The polyether-macrolide antibiotic, boromycin, was isolated as a potent anti-human immunodeficiency virus (HIV) antibiotic from a fermentation broth of Streptomyces sp. A-3376. Boromycin was found to strongly inhibit the replication of the clinically isolated HIV-1 strain as well as the cultured strain in in vitro laboratory experiments. The mechanism for the anti-HIV activity of boromycin is suggested to involve blocking the later stage of HIV infection, and probably the maturity step for replication of the HIV molecule.
Glucosamine, 1-Deoxynojirimycin, Glycoside Hydrolases, Molecular Structure, Dextran Sulfate, RNA-Directed DNA Polymerase, Antiviral Agents, HIV Reverse Transcriptase, Streptomyces, Anti-Bacterial Agents, Cell Line, Borates, HIV-2, HIV-1, Humans
Glucosamine, 1-Deoxynojirimycin, Glycoside Hydrolases, Molecular Structure, Dextran Sulfate, RNA-Directed DNA Polymerase, Antiviral Agents, HIV Reverse Transcriptase, Streptomyces, Anti-Bacterial Agents, Cell Line, Borates, HIV-2, HIV-1, Humans
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