PI-220, a New Platelet Aggregation Inhibitor

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1993 English Publisher:Oxford University Press (OUP)Journal:Bioscience, Biotechnology, and Biochemistry, volume 57, pages 766-769 (issn: 0916-8451, eissn: 1347-6947,

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Authors: Kagamizono, Terumi; Kawashima, Akira; Kishimura, Yuko; Yamagishi, Michio; Tsuchida, Yukiko; Kondo, Hideaki; Hanada, Kazunori;

doi: 10.1271/bbb.57.766

PI-220, a New Platelet Aggregation Inhibitor

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Abstract

PI-220 was found in a culture broth of Streptomyces sp. A8059, which had been isolated from a soil sample collected in Okinawa Prefecture, Japan.PI-220 inhibited aggregation of rabbit platelets with an IC50 value of 1.0-2.1 × 10-3 M.

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