Inhibited Apoptosis of C2C12Myoblasts by aEupatorium chinense var. simplicifoliumRoot Extract
Copyright policy )Inhibited Apoptosis of C2C12Myoblasts by aEupatorium chinense var. simplicifoliumRoot Extract
We investigated the effects of a Eupatorium chinense var. simplicifolium (EUC) root extract on muscle disorders and explored the underlying mechanism for oxidative stress-induced C(2)C(12) myoblast damage. An EUC pre-treatment reduced the decreased cell viability after an H2O2 treatment. The heat shock protein (HSP) 70 level increased, and the phosphorylation of Jun amino-terminal kinases (JNKs) decreased in the EUC-pre-treated C(2)C(12) myoblasts. The results of the present study demonstrate the potential benefit of a herbal medicine in treating oxidative stress-related muscle disorders.
- Yonsei University Korea (Republic of)
- Fraunhofer Society Germany
- Fraunhofer Institute for Nondestructive Testing Germany
- National Institute of Horticultural and Herbal Science Korea (Republic of)
muscle atrophy, Plant Extracts, <i>Eupatorium chinense var. simplicifolium</i>, Eupatorium, Apoptosis, Plant Roots, Cell Line, Myoblasts, Oxidative Stress, HSP70
muscle atrophy, Plant Extracts, <i>Eupatorium chinense var. simplicifolium</i>, Eupatorium, Apoptosis, Plant Roots, Cell Line, Myoblasts, Oxidative Stress, HSP70
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