Differential Dose Response of mTOR Signaling to Oral Administration of Leucine in Skeletal Muscle and Liver of Rats
Copyright policy )Differential Dose Response of mTOR Signaling to Oral Administration of Leucine in Skeletal Muscle and Liver of Rats
Phosphorylation of eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and 70-kDa ribosomal protein S6 kinase (S6K1) in the rat liver increased in proportion to the amount of leucine administered, ranging from 0.169 to 1.35 g/kg of body weight. In the skeletal muscle, phosphorylation of these factors reached a plateau at 0.675 g/kg of body weight. The sensitivity of mammalian target of rapamycin (mTOR) signaling to leucine in the skeletal muscle appeared to be higher than that in the liver.
- Utsunomiya University Japan
Male, Dose-Response Relationship, Drug, TOR Serine-Threonine Kinases, Administration, Oral, liver, Rats, eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), Liver, Leucine, Animals, 70-kDa ribosomal protein S6 kinase (S6K1), leucine, skeletal muscle, Rats, Wistar, Muscle, Skeletal, Signal Transduction
Male, Dose-Response Relationship, Drug, TOR Serine-Threonine Kinases, Administration, Oral, liver, Rats, eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), Liver, Leucine, Animals, 70-kDa ribosomal protein S6 kinase (S6K1), leucine, skeletal muscle, Rats, Wistar, Muscle, Skeletal, Signal Transduction
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