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Bioscience Biotechnology and Biochemistry
Article . 2011 . Peer-reviewed
Full-Text: http://www.jstage.jst.go.jp/article/bbb/75/8/75_110306/_pdf
Data sources: Japan Link Center
Bioscience Biotechnology and Biochemistry
Article . 2011 . Peer-reviewed
Data sources: Crossref
Bioscience Biotechnology and Biochemistry
Article . 2012
Data sources: Europe PubMed Central
https://dx.doi.org/10.1271/bbb...
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Melanin Biosynthesis Inhibitors from TarragonArtemisia dracunculus

descriptionPublicationkeyboard_double_arrow_right Article 23 Aug 2011 English Publisher:Informa UK LimitedJournal:Bioscience, Biotechnology, and Biochemistry, volume 75, pages 1,628-1,630 (issn: 0916-8451, eissn: 1347-6947, Copyright policy )
Authors: YAMADA, Masayoshi; NAKAMURA, Kazuhiko; WATABE, Taeko; OHNO, Osamu; KAWAGOSHI, Masaru; MARU, Norihito; UOTSU, Nobuo; +3 Authors

doi: 10.1271/bbb.110306

pmid: 21821921

Melanin Biosynthesis Inhibitors from TarragonArtemisia dracunculus

Abstract

The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10-dynoic acid. The respective EC(50) values for melanin biosynthesis inhibition were 1.8 and 2.3 µg/mL for 1 and 2.

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Keywords

Melanins, Magnetic Resonance Spectroscopy, Skin Neoplasms, alkamide, Cell Survival, Plant Extracts, Polyunsaturated Alkamides, Melanoma, Experimental, melanin biosynthesis inhibitor, α-melanocyte-stimulating hormone (α-MSH), Inhibitory Concentration 50, Mice, Artemisia, alpha-MSH, Tumor Cells, Cultured, Animals, Humans, skin-whitening

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    popularity
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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
8
Average
Average
Average