Disruption of Ion Homeostasis by Verrucosin and a Related Compound

descriptionPublicationkeyboard_double_arrow_right Article 23 May 2011 English Publisher:Informa UK LimitedJournal:Bioscience, Biotechnology, and Biochemistry, volume 75, pages 1,000-1,002 (issn: 0916-8451, eissn: 1347-6947,

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Authors: AKIYAMA, Koichi; TONE, Junichi; YAMAUCHI, Satoshi; SUGAHARA, Takuya; MARUYAMA, Masafumi; KAKINUMA, Yoshimi;

doi: 10.1271/bbb.110004

pmid: 21597167

Disruption of Ion Homeostasis by Verrucosin and a Related Compound

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Abstract

We have found that (-)-virgatusin and related compounds have antimicrobial and antifungal activity. To identify further biological activities of these compounds, we tested the activity of acridine orange efflux, which shows ionophore-like disruption of cellular ion homeostasis activity. After testing 31 compounds, we found that verrucosin and a related compound had disruption activity.

Related Organizations

Ehime University
Japan

Keywords

lignan, ionophore, Ions, Acridine Orange, Lignans, Cell Line, Tumor, Homeostasis, Humans, ion homeostasis, Furans, verrucosin

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