Heparin-induced thrombocytopenia (HIT) is an immune-mediated condition causing thrombocytopenia and paradoxical thrombosis after exposure to heparin or low-molecular-weight heparin. It has been rarely reported by Fondaparinux, an artificial pentasaccharide similar to heparin. This manuscript presents a case of HIT associated with fondaparinux use. doi: https://doi.org/10.12669/pjms.37.2.3522 How to cite this:Malik J, Javed N, Kamin M. Fondaparinux-associated Thrombocytopenia. Pak J Med Sci. 2021;37(2):598-599. doi: https://doi.org/10.12669/pjms.37.2.3522 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.