Direct observation therapy-highly active antiretroviral therapy in a resource-limited setting: the use of community treatment support can be effective
Copyright policy )Direct observation therapy-highly active antiretroviral therapy in a resource-limited setting: the use of community treatment support can be effective
This study examines the use of various direct observation therapy-HAART treatment support modalities in Jos, Nigeria. A 12-month observational study enrolling 175 antiretroviral naïve patients into four arms of direct observation therapy-HAART (highly active antiretroviral therapy); daily observed therapy (DOT), twice weekly observed therapy (TWOT), weekly observed therapy (WOT) and self-administered therapy (SAT), examined community treatment support using family and community members. Treatment outcomes were much better in the treatment-supported groups compared with the control self-therapy group. CD4 cell increases were 218/ μL (DOT), 267/ μL (TWOT), 205/ μL (WOT) versus 224/ μL (SAT), whereas plasma HIV-1 RNA reached undetectable levels (<400 copies/mL) in 91%, 88%, 84% versus 79% of patients in the DOT, TWOT, WOT versus SAT groups, respectively, at 48 weeks. We, therefore, strongly support the use of treatment support in our settings.
- Harvard University United States
- Jos University Teaching Hospital Nigeria
Adult, Male, Anti-HIV Agents, Nigeria, HIV Infections, Middle Aged, Viral Load, CD4 Lymphocyte Count, Directly Observed Therapy, Treatment Outcome, Antiretroviral Therapy, Highly Active, HIV-1, Humans, Patient Compliance, RNA, Viral, Female, Aged
Adult, Male, Anti-HIV Agents, Nigeria, HIV Infections, Middle Aged, Viral Load, CD4 Lymphocyte Count, Directly Observed Therapy, Treatment Outcome, Antiretroviral Therapy, Highly Active, HIV-1, Humans, Patient Compliance, RNA, Viral, Female, Aged
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).26 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!