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Quantitative studies of lymphoid organs, blood and lymph in inbred athymic and euthymic LEW rats under germfree and specified-pathogen-free conditions

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1987 Denmark Publisher:SAGE PublicationsJournal:Laboratory Animals, volume 21, pages 342-347 (issn: 0023-6772, eissn: 1758-1117,

Authors: Klausen, B; Hougen, H P;

doi: 10.1258/002367787781363318

pmid: 2961927

Quantitative studies of lymphoid organs, blood and lymph in inbred athymic and euthymic LEW rats under germfree and specified-pathogen-free conditions

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Abstract

Four groups of inbred male LEW rats were examined: A, germfree athymic; B, specified pathogen free (SPF) athymic; C, germfree euthymic; D, SPF euthymic. All animals were killed at 18 weeks and compared with respect to body weight, histological appearance and cell density of the lymphoid organs, haematological values and differential counts of bone marrow, peripheral blood and lymph. Athymic rats had a lower body weight, less densely populated lymphoid organs, and fewer lymphocytes in the blood and lymph compared with euthymic animals. No difference was seen between athymic rats under germfree and SPF conditions, and in general the differences between athymic and euthymic animals were less pronounced under germfree conditions.

Country

Denmark

Related Organizations

University of Copenhagen
Denmark
University of Copenhagen
Denmark

Keywords

Male, Lymphoid Tissue, Nude, Inbred Strains, Bone Marrow Cells, Thymus Gland, Rats, Mutant Strains, Leukocyte Count, Rats, Nude, Animals, Germ-Free Life, Lymphocytes, Inbred Lew, Body Weight, Rats, Inbred Strains, Organ Size, Rats, Specific Pathogen-Free Organisms, Mutant Strains, Rats, Inbred Lew, Lymph, Lymph Nodes, Spleen

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	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average