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Characteristics of Attenuating Effects of Rebamipide, an Anti-ulcer Agent, on Oxidative Burst of Human Neutrophils

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2003 English Publisher:Japanese Pharmacological SocietyJournal:Journal of Pharmacological Sciences, volume 91, pages 153-157 (issn: 1347-8613, eissn: 1347-8648,

Authors: Qiang Liu; Tadashi Shimoyama; Kazuo Sugawara; Shinsaku Fukuda; Yoshihiro Fukuda; Shigeyuki Nakaji;

doi: 10.1254/jphs.91.153

pmid: 12686760

Characteristics of Attenuating Effects of Rebamipide, an Anti-ulcer Agent, on Oxidative Burst of Human Neutrophils

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Abstract

The aim of this study was to characterize the effects of rebamipide on the oxidative burst of human neutrophils. The neutrophil oxidative burst was measured in the presence of rebamipide and cimetidine using lucigenin- or luminol-dependent chemiluminescence (LgCL or LmCL). Rebamipide inhibited the LmCL response stimulated with opsonized zymosan, 12-myristate 13-acetate phorbol, and calcium ionophore in a dose-dependent manner, but the LgCL response was inhibited when neutrophils were stimulated with opsonized zymosan. LmCL response was also dose-dependently attenuated by rebamipide even in the presence of cimetidine. Thus, addition of rebamipide to H(2)-receptor antagonists can be considered for the treatment of gastric mucosal injury associated with oxidative stress.

Related Organizations

Hirosaki University
Japan

Keywords

Adult, Male, Alanine, Dose-Response Relationship, Drug, Neutrophils, RM1-950, In Vitro Techniques, Quinolones, Anti-Ulcer Agents, Histamine H2 Antagonists, Depression, Chemical, Luminescent Measurements, Humans, Therapeutics. Pharmacology, Cimetidine, Respiratory Burst

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