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The Japanese Journal of Pharmacology
Article . 2001 . Peer-reviewed
Full-Text: http://www.jstage.jst.go.jp/article/jjp/87/3/87_3_240/_pdf
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The Japanese Journal of Pharmacology
Article . 2001 . Peer-reviewed
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The Japanese Journal of Pharmacology
Article
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The Japanese Journal of Pharmacology
Article . 2002
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https://dx.doi.org/10.1254/jjp...
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Ameliorative Effects of Azaindolizinone Derivative ZSET845 on Scopolamine-Induced Deficits in Passive Avoidance and Radial-Arm Maze Learning in the Rat

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2001 English Publisher:Elsevier BVJournal:Japanese Journal of Pharmacology, volume 87, pages 240-244 (issn: 0021-5198, Copyright policy )
Authors: Yamaguchi, Yoshimasa; Higashi, Masaya; Matsuno, Toshiyuki; Kawashima, Seiichiro;

doi: 10.1254/jjp.87.240

pmid: 11885975

Ameliorative Effects of Azaindolizinone Derivative ZSET845 on Scopolamine-Induced Deficits in Passive Avoidance and Radial-Arm Maze Learning in the Rat

Abstract

Effects of ZSET845 (3,3-dibenzylimidazo[1,2-a]pyridin-2-(3H)-one), a newly synthesized cognitive enhancer, and donepezil and tacrine on the scopolamine-induced cognitive deficits in rats were examined in passive avoidance and radial-arm maze tasks. ZSET845 (0.01 mg/kg) showed a greater ameliorative effect than donepezil (0.1 mg/kg) or tacrine (1 mg/kg) in the passive avoidance task. In the radial-arm maze task, ZSET845 (0.1 mg/kg) also showed a greater effect than donepezil (10 mg/kg) or tacrine (10 mg/kg). ZSET845 induced an increase in the choline acetyltransferase (ChAT) activity in the hippocampus, suggesting that the ameliorative effects of ZSET845 are related to the increase in the ChAT activity in the hippocampus.

Keywords

Male, Dose-Response Relationship, Drug, Pyridones, Scopolamine, Hippocampus, Passive avoidance, Radial-arm maze, Choline O-Acetyltransferase, Rats, Rats, Sprague-Dawley, Cognition, Choline acetyltransferase, Piperidines, Alzheimer Disease, Enzyme Induction, Indans, Avoidance Learning, Tacrine, Animals, Donepezil, Maze Learning

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
16
Average
Top 10%
Average
gold