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The Japanese Journal of Pharmacology
Article . 1996 . Peer-reviewed
Full-Text: http://www.jstage.jst.go.jp/article/jphs1951/71/1/71_1_85/_pdf
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The Japanese Journal of Pharmacology
Article . 1996 . Peer-reviewed
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The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology
Article . 1997
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https://dx.doi.org/10.1254/jjp...
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Prostanoid Receptor-Mediated Calcium Signaling in Cultured Rat Astrocytes

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1996 English Publisher:Elsevier BVJournal:Japanese Journal of Pharmacology, volume 71, pages 85-87 (issn: 0021-5198, Copyright policy )
Authors: Kitanaka, Junichi; Takuma, Kazuhiro; Kondo, Kaoru; Baba, Akemichi;

doi: 10.1254/jjp.71.85

pmid: 8791175

Prostanoid Receptor-Mediated Calcium Signaling in Cultured Rat Astrocytes

Abstract

We investigated prostanoid-induced intracellular Ca2+ mobilization in Ca(2+)-sensitive dye fura-2-loaded cultured astrocytes. The thromboxane (TX) A2 analog STA2 (9,11-epithio-11,12-methano-TXA2) and/or prostaglandin (PG) F2 alpha (each used at 1 microM) stimulated intracellular Ca2+ mobilization in single cultured rat type 1 astrocytes. Three response patterns were observed: only STA2-sensitive, only PGF2 alpha-sensitive, and both prostanoids-sensitive cells. The Ca2+ response was prostanoid-dose-dependent (0.1 - 1 microM) and showed a rapid spike-like Ca2+ rise that peaked within 30 sec after the stimulation by the ligand. These observations suggest that type 1 astrocytes are heterogeneous with respect to the expression of receptors for TXA2 and PGF2 alpha, which are linked to Ca2+ mobilization.

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Keywords

Receptors, Prostaglandin, Dinoprost, Rats, Rats, Sprague-Dawley, Ca<SUP>2+</SUP> mobilization, Thromboxane A2, Astrocytes, Animals, Calcium, Thromboxane A<SUB>2</SUB>, Astrocyte, Fura-2, Cells, Cultured, Fluorescent Dyes, Signal Transduction

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    popularity
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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Average
Average
Average
gold