The Role of Intestinal Bacteria in the Transformation of Sodium Picosulfate
Copyright policy )The Role of Intestinal Bacteria in the Transformation of Sodium Picosulfate
Sodium picosulfate, a laxative, was biotransformed to 4,4'-dihydroxydiphenyl-(2 pyridyl)-methane by intestinal flora that produced a novel sulfotransferase (not sulfatase). The biotransformation was activated by adding phenolic compounds such as phenol, acetaminophen and flavonoids. The enzyme activity related to this biotransformation was the highest in the contents of the caecum region of the intestine. The enzyme activity was 3.0 mumole/hr/g wet feces in humans and 0.75 in rats (pH 8.0). The optimal pH was 9.0.
- University of Toyama Japan
- Kyung Hee University Korea (Republic of)
Bisacodyl, Flavonoids, Male, Cathartics, Eubacterium, Rats, Inbred Strains, Hydrogen-Ion Concentration, Carboxylesterase, Rats, Intestines, Feces, Phenols, Picolines, Organometallic Compounds, Animals, Humans, Citrates, Carboxylic Ester Hydrolases, Biotransformation, Acetaminophen
Bisacodyl, Flavonoids, Male, Cathartics, Eubacterium, Rats, Inbred Strains, Hydrogen-Ion Concentration, Carboxylesterase, Rats, Intestines, Feces, Phenols, Picolines, Organometallic Compounds, Animals, Humans, Citrates, Carboxylic Ester Hydrolases, Biotransformation, Acetaminophen
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