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Pharmacological analysis of sinus rhythm.

Name: Pharmacological analysis of sinus rhythm.
Keywords: Sympathetic Nervous System, Morphine, Tyramine, Adrenergic beta-Agonists, In Vitro Techniques, Acetylcholine, Feedback, Norepinephrine, Dogs, Biological Clocks

洞調律の薬理

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1993 Japanese Publisher:Japanese Pharmacological SocietyJournal:Folia Pharmacologica Japonica, volume 102, pages 257-270 (issn: 0015-5691, eissn: 1347-8397,

Authors: Yasuyuki Furukawa; Shigetoshi Chiba;

doi: 10.1254/fpj.102.257

pmid: 7902827

Pharmacological analysis of sinus rhythm.

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Abstract

The SA nodal pacemaker activity is regulated dominantly by autonomic nervous elements, i.e., sympathetic and parasympathetic nervous factors. In addition, circulatory bioactive substances and physicochemical factors also modify changes in sinus rate. Exogenously applied substances exert their actions on sinus rate directly and/or indirectly. The mechanisms of bradycardia and tachycardia induced by electrical nerve stimulation or exogenous substances are reviewed mostly by describing the results from experiments in isolated canine SA node preparations which were perfused with blood. In this review, newly developed bradycardic agents are introduced in addition to descriptions of numerous active substances developed in the past.

Related Organizations

Shinshu University
Japan

Keywords

Sympathetic Nervous System, Morphine, Tyramine, Adrenergic beta-Agonists, In Vitro Techniques, Acetylcholine, Feedback, Norepinephrine, Dogs, Biological Clocks, Heart Rate, Parasympathetic Nervous System, Animals, Stress, Mechanical, Sinoatrial Node

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