Synthesis of Related Compounds of Thiosemi-carbazide. IV. 1-(1, 3, 4-Thiadiazol-2-yl)-2-pyrazolin-5-one and Tetrazolo [4, 5-a]-1, 3, 4-thiadiazole Derivatives.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1958 English Publisher:Pharmaceutical Society of JapanJournal:Chemical and Pharmaceutical Bulletin, volume 6, pages 382-386 (issn: 0009-2363, eissn: 1347-5223,

Copyright policy )

Authors: M, KANAOKA;

doi: 10.1248/cpb.6.382

pmid: 13585513

Synthesis of Related Compounds of Thiosemi-carbazide. IV. 1-(1, 3, 4-Thiadiazol-2-yl)-2-pyrazolin-5-one and Tetrazolo [4, 5-a]-1, 3, 4-thiadiazole Derivatives.

- Summary
- Subjects
- Metrics

Abstract

1) 1-(5-R-1, 3, 4-Thiadiazol-2-yl)-3-methyl-4-R'-2-pyrazolin-5-one (R'=H, iso-C3H7) (III) were synthesized starting with 2-hydrazino-5-R-1, 3, 4-thiadiazole (I : R=CH3, C2H5, n-C3H7, iso-C4H9, C6H5), and reacting them with ethyl acetoacetate or ethyl 3-acetyliso-valerate to form 5-R-1, 3, 4-thiadiazolylhydrazone (II). 2) 2-R-Tetrazolo [4, 5-a]-1, 3, 4-thiadiazole, compound analogous to 8-azaguanine, were synthesized by the reaction of 2-hydrazino-5-R-1, 3, 4-thiadiazole (I) with sodium nitrite in diluted acetic acid.

Related Organizations

University of Toyama
Japan

Keywords

Azoles, Thiazoles, Thiadiazoles, Pyrazolones, Semicarbazides

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	10
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average