Iodine-Catalyzed Etherification of Morroniside
Copyright policy )Iodine-Catalyzed Etherification of Morroniside
In this study, we describe a highly selective etherification procedure of unprotected morroniside catalyzed by molecular iodine in acetone. The etherification reaction furnished 7-O-alkyl ether derivatives in reasonable yields within few hours under neutral conditions. Studies of the obtained products on cytotoxicity activity in colon 26-L5 cell line were examined. Among the tested compounds, 7-O-dodecylmorroniside showed moderate cytotoxic activity, having IC50 values equal to 20.9 microM.
- Gifu University Japan
- University of Dar es Salaam Tanzania (United Republic of)
- National University Corporation Gifu University Japan
- University of Toyama Japan
Molecular Structure, Strychnos, Antineoplastic Agents, Phytogenic, Plant Roots, Catalysis, Acetone, Mice, Cell Line, Tumor, Colonic Neoplasms, Animals, Glycosides, Ethers, Iodine
Molecular Structure, Strychnos, Antineoplastic Agents, Phytogenic, Plant Roots, Catalysis, Acetone, Mice, Cell Line, Tumor, Colonic Neoplasms, Animals, Glycosides, Ethers, Iodine
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