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Myeloperoxidase Inhibitory and Radical Scavenging Activities of Flavones from Pterogyne nitens

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2008 Brazil English Publisher:Pharmaceutical Society of JapanJournal:Chemical and Pharmaceutical Bulletin, volume 56, pages 723-726 (issn: 0009-2363, eissn: 1347-5223, Copyright policy )
Authors: Fernandes, Daniara Cristina; Regasini, Luis Octávio; Vellosa, José Carlos Rebuglio; Pauletti, Patrícia Mendonça; Castro-Gamboa, Ian; Bolzani, Vanderlan da Silva; Oliveira, Olga Maria Mascarenhas; +1 Authors

doi: 10.1248/cpb.56.723

pmid: 18451567

handle: 11449/70410

Myeloperoxidase Inhibitory and Radical Scavenging Activities of Flavones from Pterogyne nitens

Abstract

Two new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-beta-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-beta-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1-6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox.

Country
Brazil
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Keywords

Magnetic Resonance Spectroscopy, Radical scavenging, Glucosides, Picrates, nitensoside a, pedalitin 6 o beta glucopyranoside, nitensoside b, flavone derivative, controlled study, Benzothiazoles, drug inhibition, Enzyme Inhibitors, Flavone, Peroxidase, Myeloperoxidase, nonhuman, sorbifolin 6 o beta glucopyranoside, Biphenyl Compounds, IC 50, Fabaceae, legume, Free Radical Scavengers, Flavones, Plant Leaves, myeloperoxidase, drug structure, nuclear magnetic resonance, pedalitin, sorbifolin, Pterogyne nitens, Antioxidant, Sulfonic Acids, glucoside

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
40
Top 10%
Top 10%
Top 10%
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gold