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Chemical and Pharmaceutical Bulletin
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Microbial Transformation of the Steroidal Alkaloid Dictyophlebine by Rhizopus stolonifer

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2007 Germany English Publisher:Pharmaceutical Society of JapanJournal:Chemical and Pharmaceutical Bulletin, volume 55, pages 682-684 (issn: 0009-2363, eissn: 1347-5223, Copyright policy )
Authors: Devkota, Krishna Prasad; Choudhary, Muhammad Iqbal; Nawaz, Sarfaraz Ahmed; Lannang, Alain Meli; Lenta, Bruno Ndjakou; Fokou, Patrice Aime; Sewald, Norbert;

doi: 10.1248/cpb.55.682

pmid: 17409573

Microbial Transformation of the Steroidal Alkaloid Dictyophlebine by Rhizopus stolonifer

Abstract

The microbial transformation of a steroidal alkaloid, dictyophlebine (1) with Rhizopus stolonifer (ATCC 10404) afforded three oxidized metabolites 2-4. Compound 2 was found to be a new product. These metabolites were structurally characterized on the basis of modern spectroscopic techniques. Their inhibitory activity towards acetyl- and butyrylcholinesterase has been evaluated and the new product 2 has been found to be more potent than the parent compound and other metabolites.

Country
Germany
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Keywords

Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, <i>Rhizopus stolonifer</i>, dictyophlebine, Spectrophotometry, Ultraviolet, Steroids, oxidized metabolite, cholinesterase inhibition, Rhizopus stolonifer, Biotransformation, Rhizopus

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
10
Average
Top 10%
Top 10%
gold