Solvolysis Study of Cycliciminomitomycins

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2007 English Publisher:Pharmaceutical Society of JapanJournal:Chemical and Pharmaceutical Bulletin, volume 55, pages 482-487 (issn: 0009-2363, eissn: 1347-5223,

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Authors: Younghwa, Na;

doi: 10.1248/cpb.55.482

pmid: 17329899

Solvolysis Study of Cycliciminomitomycins

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Abstract

The solvolysis rates for the substituted C(7)-cyclohexylamino- or C(8)-cyclohexyliminomitomycins 8-19 were determined in buffered methanolic solutions (0.06 M bis-Tris.HCl, pH: 5.5) at 25 degrees C and then compared with mitomycin C (1) and porfiromycin. Kinetic studies showed that C(8)-cyclohexyliminomitomycins 8-13 underwent solvolysis 150-230 times faster than mitomycin C (1) to give C(1)-methoxymitosene products. The solvolysis rates were slightly faster than that reported for 6. The C(7)-(2'-hydroxy)cyclohexylaminomitomycins 16-19 exhibited comparable solvolysis rates with 1 and porfiromycin.

Related Organizations

Catholic University of Daegu
Korea (Republic of)

Keywords

Molecular Structure, Hydrolysis, Mitomycins

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