Synthesis of Sialyl Lewis X-Polysaccharide Conjugates.
Copyright policy )Synthesis of Sialyl Lewis X-Polysaccharide Conjugates.
Sialyl Lewis X (SLeX) is well known as a ligand of the cell adhesion molecule E-selectin which is specifically expressed at inflammatory lesion sites. We have synthesized several SLeX-polysaccharide conjugates and examined their potential for drug delivery to inflammatory lesions. The AUC (area under the blood concentration-time curve) 0-24 h of SLeX-CMCht (1), SLeX-CMPul (2) and SLeX-DSH (3) at the inflammatory lesion was about 60-, 300-, and 30-fold higher than that of the monovalent SLeX (7), respectively. Moreover, 1 showed 2-fold higher accumulation in the inflammatory lesion than SLN-CMCht (4), and 2 showed 2.5-fold higher accumulation than SLN-CMPul (5).
- Eisai Japan
Male, Mice, Inbred ICR, E-selectin, Molecular Sequence Data, Oligosaccharides, In Vitro Techniques, carboxymethyl chitosan, Mice, Drug Delivery Systems, Carbohydrate Sequence, Polysaccharides, sialyl Lewis X, Area Under Curve, active-targeting drug delivery system, carboxymethyl pullulan, N-desulfated heparin, Animals, Edema, Sialyl Lewis X Antigen
Male, Mice, Inbred ICR, E-selectin, Molecular Sequence Data, Oligosaccharides, In Vitro Techniques, carboxymethyl chitosan, Mice, Drug Delivery Systems, Carbohydrate Sequence, Polysaccharides, sialyl Lewis X, Area Under Curve, active-targeting drug delivery system, carboxymethyl pullulan, N-desulfated heparin, Animals, Edema, Sialyl Lewis X Antigen
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