Purealidins J-R, New Bromotyrosine Alkaloids from the Okinawan Marine Sponge Psammaplysilla purea.
Copyright policy )Purealidins J-R, New Bromotyrosine Alkaloids from the Okinawan Marine Sponge Psammaplysilla purea.
Nine new bromotyrosine alkaloids, purealidins J-R (1-9), have been isolated from the Okinawan marine sponge Psammaplysilla purea and the structures were elucidated on the basis of spectroscopic data. A hydroxy group as C-1 of purealidins M-O (4-6) may be biosynthetically derived from ring-opening of a spirocyclohexadienyl-isoxazole unit of purealidin J (1), aerophobin-1 (10), and purealidin L (3), respectively. Purealidins N (5), P (7), and Q (8) were cytotoxic to tumor cell lines, while purealidins J (1), K (2), P (7), and Q (8) showed moderate inhibitory activity against epidermal growth factor (EGF) receptor kinase.
- Hokkaido Bunkyo University Japan
- Kanazawa University Japan
- Hokkaido University Japan
sponge, cytotoxic, epidermal growth factor receptor kinase, purealidin, bromotyrosine alkaloid, Psammaplysilla purea
sponge, cytotoxic, epidermal growth factor receptor kinase, purealidin, bromotyrosine alkaloid, Psammaplysilla purea
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).68 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!