
doi: 10.1248/cpb.40.2452
pmid: 1446367
The root heartwood of Dalbergia odorifera T. Chen (Leguminosae) is a Chinese medicinal drug (Japanese name koshinko) used for a stagnant blood syndrome (stagnation of disordered blood; Japanese, oketsu). In addition to 10 known compounds, five new phenolic compounds, isomucronustyrene and hydroxyobtustyrene (cinnamylphenols), (+)-isoduartin (isoflavan), odoriflavene (isoflav-3-ene) and (-)-odoricarpan (pterocarpan) were isolated and their structures were elucidated on the basis of chemical and spectroscopic methods. Of the fifteen compounds isolated, cinnamylphenols, isoflavans, isoflavene and benzoic acid derivative significantly inhibited prostaglandin biosynthesis as well as platelet aggregation induced by arachidonic acid.
Medicine, East Asian Traditional, Plants, Medicinal, Platelet Aggregation, Prostaglandin Antagonists, Humans, Cyclooxygenase Inhibitors, In Vitro Techniques, Platelet Aggregation Inhibitors
Medicine, East Asian Traditional, Plants, Medicinal, Platelet Aggregation, Prostaglandin Antagonists, Humans, Cyclooxygenase Inhibitors, In Vitro Techniques, Platelet Aggregation Inhibitors
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