Platelet Aggregation Inhibitors from Populus sieboldii MIQUEL.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1992 English Publisher:Pharmaceutical Society of JapanJournal:Chemical and Pharmaceutical Bulletin, volume 40, pages 2,191-2,192 (issn: 0009-2363, eissn: 1347-5223,

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Authors: K, Kagawa; K, Tokura; K, Uchida; H, Kakushi; T, Shike;

doi: 10.1248/cpb.40.2191

pmid: 1423779

Platelet Aggregation Inhibitors from Populus sieboldii MIQUEL.

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Abstract

The water extract of Populus sieboldii Miquel (Salicaceae) inhibited arachidonic acid-induced platelet aggregation. Pyrocatechol and salicyl alcohol were isolated as active constituents. Pyrocatechol showed an inhibitory effect on platelet aggregation induced by arachidonic acid with IC100 value of 4 microM, which was 25 times more potent than aspirin.

Keywords

Platelet Aggregation, Humans, In Vitro Techniques, Platelet Aggregation Inhibitors, Drugs, Chinese Herbal

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