Psychotropic agents. I. Synthesis of 1-pyridinyl-1-butanones, 1-indolyl-1-butanones and the related compounds.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1978 English Publisher:Pharmaceutical Society of JapanJournal:Chemical and Pharmaceutical Bulletin, volume 26, pages 3,296-3,305 (issn: 0009-2363, eissn: 1347-5223,

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Authors: M, Sato; H, Tagawa; A, Kosasayama; F, Uchimaru; H, Kojima; T, Yamasaki; T, Sakurai;

doi: 10.1248/cpb.26.3296

pmid: 729117

Psychotropic agents. I. Synthesis of 1-pyridinyl-1-butanones, 1-indolyl-1-butanones and the related compounds.

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Abstract

In order to search for new psychotropic agents, several 1-butanone derivatives (VIII) substituted by pyridine, indole or quinoline were synthesized. And the carbonyl group of VIII was modified to methylene (XII), secondary alcohol (XIII) and vinyl (XIV). The effects of the compounds on spontaneous motor activity and rotarod test in mice were determined. The structure-activity relationships of these derivatives are discussed.

Keywords

Mice, Psychotropic Drugs, Indoles, Pyridines, Animals, Motor Activity, Butanones

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