New sulfhydryl compounds with potent antihypertensive activities.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1978 English Publisher:Pharmaceutical Society of JapanJournal:Chemical and Pharmaceutical Bulletin, volume 26, pages 1,333-1,335 (issn: 0009-2363, eissn: 1347-5223,

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Authors: I, Mita; J, Iwao; M, Oya; T, Chiba; T, Iso;

doi: 10.1248/cpb.26.1333

pmid: 207454

New sulfhydryl compounds with potent antihypertensive activities.

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Abstract

(4R)-3-(Mercaptoacyl)-4-thiazolidinecarboxylic acids (III) were synthesized and their inhibitory activities against angiotensin-converting enzyme (ACE) were examined in vitro and in vivo. (4R)-3-[(2S)-3-Mercapto-2-methylpropanoyl]-4-thiazolidinecarboxylic acid (4a) was the most potent orally active inhibitor of ACE among the derivatives and its activity was almost same as that of (2S)-1-[(2S)-3-mercapto-2-methylpropanoyl] proline (8).

Keywords

Guinea Pigs, Animals, Angiotensin-Converting Enzyme Inhibitors, Sulfhydryl Compounds, Antihypertensive Agents

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