Urinary and biliary metabolites of 17.ALPHA.-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione in the rabbit.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1974 English Publisher:Pharmaceutical Society of JapanJournal:Chemical and Pharmaceutical Bulletin, volume 22, pages 2,824-2,829 (issn: 0009-2363, eissn: 1347-5223,

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Authors: T, Abe; A, Kambegawa;

doi: 10.1248/cpb.22.2824

pmid: 4143183

Urinary and biliary metabolites of 17.ALPHA.-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione in the rabbit.

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Abstract

Ten metabolites of 17α-acetoxy-6-chloro-4, 6-pregnadiene-3, 20-dione were isolated from urine and bile of the rabbit and their chemical structures were determined. The urinary main metabolite was 17α-acetoxy-2ξ, 3ξ-dihydroxy-5ξ-pregnan-20-one. The biliary main metabolite was 17α-acetoxy-6-chloro-2ξ, 3ξ-dihydroxy-4, 6-pregnadien-20-one. The administered compound was metabolized through two courses, one was oxidation at C-2 and another was dechlorination at C-6, in the rabbit. A small amount of the metabolite oxidized at C-21 was identified from urine.

Related Organizations

Tohoku University
Japan

Keywords

Male, Chlormadinone Acetate, Animals, Bile, Rabbits

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