Effects of Inhibiting the Proteasomal Degradation of Estrogen Receptor .ALPHA. on Estrogen Receptor .ALPHA. Activation under Hypoxic Conditions
Copyright policy )Effects of Inhibiting the Proteasomal Degradation of Estrogen Receptor .ALPHA. on Estrogen Receptor .ALPHA. Activation under Hypoxic Conditions
Hypoxia, which is intimately associated with the biology of breast carcinomas, modulates the level of estrogen receptor (ER) alpha expression and transactivation. We investigated the effect of blocking ER degradation on ERalpha-mediated transactivation under hypoxic conditions using the proteasome inhibitor MG132. Pretreatment with MG132 blocked hypoxia-induced degradation of ERalpha protein. Our data imply that ERalpha proteasomal inhibition is linked to receptor transactivation under hypoxia.
- Sejong University Korea (Republic of)
- Biotechnology Institute United States
Transcriptional Activation, Leupeptins, Carcinoma, Estrogen Receptor alpha, Antineoplastic Agents, Breast Neoplasms, Cell Line, Tumor, Humans, Female, Hypoxia, Proteasome Inhibitors
Transcriptional Activation, Leupeptins, Carcinoma, Estrogen Receptor alpha, Antineoplastic Agents, Breast Neoplasms, Cell Line, Tumor, Humans, Female, Hypoxia, Proteasome Inhibitors
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