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Biological and Pharmaceutical Bulletin
Article . 2003 . Peer-reviewed
Data sources: Crossref
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Trypsinogen hL Expressed in the Human Lung Is a New Member of the Trypsinogen Family.

Authors: Imamura, Yasuhiro; Katsu, Masataka; Sakai, Kaoru; Okumura, Yuushi; Ariga, Hiroyoshi; Kido, Hiroshi;

Trypsinogen hL Expressed in the Human Lung Is a New Member of the Trypsinogen Family.

Abstract

Molecular cloning of cDNA encoding a new member of the trypsinogen family, named trypsinogen hL, was carried out by PCR using human lung cDNAs as templates. The primary structure of trypsinogen hL was found to be a prepro-protein and a catalytic triad, 64His, 108Asp and 201Ser. It was also found that trypsinogen hL is specifically expressed in the human lung, the expression level being 30-times higher than those in other tissues tested. A phylogenic tree analysis showed that trypsinogen hL is a new member of the trypsinogen family, a family of serine protease family proteins.

Keywords

DNA, Complementary, Base Sequence, Reverse Transcriptase Polymerase Chain Reaction, Serine Endopeptidases, Gene Expression, Sequence Homology, Blotting, Northern, Evolution, Molecular, Trypsinogen, Humans, RNA, Messenger, Cloning, Molecular, Lung, Sequence Alignment

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Average
Average
Average
gold