Cytotoxic Activities and Structure-Cytotoxic Relationships of Steroidal Saponins.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2001 English Publisher:Pharmaceutical Society of JapanJournal:Biological and Pharmaceutical Bulletin, volume 24, pages 1,286-1,289 (issn: 0918-6158, eissn: 1347-5215,

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Authors: Y, Mimaki; A, Yokosuka; M, Kuroda; Y, Sashida;

doi: 10.1248/bpb.24.1286

pmid: 11725965

Cytotoxic Activities and Structure-Cytotoxic Relationships of Steroidal Saponins.

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Abstract

We have systematically examined the cytotoxic activities of the steroidal saponins mainly isolated from the Liliaceae plants against HL-60 human promyelocytic leukemia cells and found several structure-activity relationships. Some steroidal saponins evaluated in the assay system showed considerable cytotoxic activities, which were almost as potent as that of etoposide used as a positive control. The activities were found to be sensitive to the monosaccharides constituting the sugar moieties and their sequences, as well as to the structures of the aglycons.

Related Organizations

University of Tokyo
Japan
Tokyo University of Pharmacy and Life Sciences
Japan

Keywords

Structure-Activity Relationship, Liliaceae, Tumor Cells, Cultured, Humans, HL-60 Cells, Diosgenin, Saponins, Cell Division, Growth Inhibitors

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