Trypanocidal Effects of Curcumin in Vitro.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1998 English Publisher:Pharmaceutical Society of JapanJournal:Biological and Pharmaceutical Bulletin, volume 21, pages 643-645 (issn: 0918-6158, eissn: 1347-5215,

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Authors: M, Nose; T, Koide; Y, Ogihara; Y, Yabu; N, Ohta;

doi: 10.1248/bpb.21.643

pmid: 9657056

Trypanocidal Effects of Curcumin in Vitro.

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Abstract

During the course of study searching for the antiparasitic agents from natural compounds, we found that curcumin showed cytotoxicity against African trypanosomes in vitro. The LD50 values of curcumin were 4.77 +/- 0.91 microM for bloodstream forms and 46.52 +/- 4.94 microM for procyclic forms of Trypanosoma brucei brucei (GUTat 3.1 clone).

Related Organizations

Nagoya City University
Japan

Keywords

Mice, Curcumin, Trypanosoma brucei brucei, Animals, Trypanocidal Agents

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