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Cell Structure and Function
Article . 2011 . Peer-reviewed
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Cell Structure and Function
Article
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Cell Structure and Function
Article . 2011
Data sources: Europe PubMed Central
https://dx.doi.org/10.1247/csf...
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Localization of SMAP2 to the TGN and its Function in the Regulation of TGN Protein Transport

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2011 English Publisher:Japan Society for Cell BiologyJournal:Cell Structure and Function, volume 36, pages 83-95 (issn: 0386-7196, eissn: 1347-3700, Copyright policy )
Authors: Tomo, Funaki; Shunsuke, Kon; Roger E, Ronn; Yuji, Henmi; Yuka, Kobayashi; Toshio, Watanabe; Keiko, Nakayama; +2 Authors

doi: 10.1247/csf.10022

pmid: 21368446

Localization of SMAP2 to the TGN and its Function in the Regulation of TGN Protein Transport

Abstract

SMAP2 is an Arf GTPase-activating protein that is located and functions on early endosome membranes. In the present study, the trans-Golgi network (TGN) was verified as an additional site of SMAP2 localization based on its co-localization with various TGN-marker proteins. Mutation of specific stretches of basic amino acid residues abolished the TGN-localization of SMAP2. Over-expression of wild-type SMAP2, but not of the mutated SMAP2, inhibited the transport of vesicular stomatitis virus-G protein from the TGN to the plasma membrane. In contrast, this transport was enhanced in SMAP2 (-/-) cells characterized by increased levels of the activated form of Arf. SMAP2 therefore belongs to an ArfGAP subtype that resides on the TGN and functions as a negative regulator of vesicle budding from the organelle.

Related Organizations
Keywords

Membrane Glycoproteins, Cell Membrane, Molecular Sequence Data, Gene Expression, Membrane Proteins, Endosomes, Mice, Protein Transport, Viral Envelope Proteins, COS Cells, Chlorocebus aethiops, Mutation, Animals, Humans, Amino Acid Sequence, HeLa Cells, trans-Golgi Network

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 12
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
12
Average
Average
Top 10%
gold